|
|
| |
New Gout Drugs ??? Pegloticase Continues Its Hopeful Path
In May 2008 the U.S. based company developing Pegloticase made another upbeat statement assessment of what they have learnt in its Phase 3 and open label extension trials. Note that Pegloticase still awaits approval from medical authorities so I am writing here about a new gout drug that is still under development.
May was a good month for gout sufferers. Febuxostat, (EU trade/brand name Adenuric), the first new major drug medication for gout in over 40 years, was approved for marketing in member countries of the European Union.
 |
60-Day Risk FREE Trial
People Said About Goutezol Gout Remedy
| "week ago i couldnt walk and was in terible pain. i though my big toe was broken i would need a surgery, but doctor said it was gout. After taking some pain killer and goutezol for 2 days i can walk again. thank you" Peter from Chicago |
 |
HOW PEGLOTICASE WORKS
What makes Pegloticase a very interesting, and more importantly, a hopeful new gout drug, is the way it works. All drugs used in gout try to cure or alleviate the disease by reducing the body's uric acid (UA) levels. They do this by either inhibiting its production or making it easier to remove.
In the world of natural gout remedies, uric acid's removal can be improved by making it more soluble. This is achieved by drinking lots of water and by raising body pH levels in various ways.
Pegloticase's answer to the excess uric acid level problem is to remove it by ingeniously converting uric acid into something else, a substance called Allantoin. Allantoin is more soluble and better excreted than uric acid. The principle comes from the way most animals do it. They do it by converting UA to Allantoin, but this is something humans cannot do naturally. Hence the formulation of Pegloticase.
TRIAL SUCCESS WITH DIFFICULT TO TREAT GOUT PATIENTS
Pegloticase is significant because its trials have focused on gout patients who have not had success with other gout drugs, or who have medical conditions which prohibit the use of them. Thus it has been tackling harder-to-treat gout cases, not the easier ones. Hard to treat cases are a significant percentage of the gout sufferer universe.
It has been having a decent degree of success.
Elimination of gout attacks In its most recent statement the developing company's most significant remark was that the extension trial group receiving Pegloticase every two weeks, there were only four gout attacks among those who had been administered Pegloticase (8 mg) every fortnight for two months, in subsequent months. And none in this group had a gout attack after five months of Pegloticase treatment, in following months. All were patients who had been through a phase 3 trial.
|
|
100% Natural and Safe Remedy
People Said About Goutezol Gout Treatment
| "I was only 30 when I got a gout attack. Goutezol really helped me to get over the attack in just two days and the ebook helps me with watching what I'm eating. My uncle have had gout problems too, so I recommended your product. Thanks a lot!" Matt, California |
|
In other patient groups there were reductions in attacks and improvement in tophi reduction. Tophi are those knobbly shaped, awkward looking, lumps of MSU crystals that often develop in longer term gout sufferers.
31% of patients who had not reduced tophi at the end of these phase 3 trials did show tophi reduction in the extension trial. It would seem that the longer a gout sufferer is able to take Pegloticase the more successful it may be, in tophi cases at least.
Other encouraging statements were that all extension trial patients who had responded earlier to treatment and who were on the every two week course maintained normal uric acid levels, (some were new joiners). 70% of those on an every four week course who had responded earlier to treatment, maintained normal uric acid levels.
This suggests that progression of the disease may be contained in difficult-to-treat cases, and therefore may not cause other medical conditions such as kidney stones heart disease and hypertension.
SIDE EFFECTS
Of course Pegloticase has caused side effects, in the extension trial in about 1 in 5 patients. The developing company has said that most were mild, moderate, or controllable. But in some cases more severe side effects have been described as including chest and back pains, muscle cramps, sweating and flushes.
Pegloticase is getting closer to an application for approval by the U.S. FDA. Its developers hope to apply for a Biologics Licence Application in September 2008, and begin marketing it in 2009.
NB. The contents of this article contain medical information not medical advice. Please always discuss gout remedies with your doctor or other health care professional, before implementing any treatment.
|
|
|
|
| |
| |
|
|
|
|
|
|
| |
| |
Learn More about Natural Gout Remedy
Gout is another from of arthritis, which is known to case sudden attacks. The gout causes are known, but unfortunately this condition can not be cured. Treatments only help in reducing the severity of the gout symptoms and to prevent, as much as possible, further gout flares.
This particular arthritis type manifests itself through sudden, painful attacks. Gout attacks develop very... 
Uricinex claims to reduce, and sometimes completely eliminate pain and swelling caused by gout. It does this thanks to a proprietary blend that reduces the level of uric acid. Micronutra, the makers of Uricinex, claims that this is all achieved naturally, without the side effects of prescription drugs. In addition, this supplement touts a high level of success, shown in an independent clinical...
b>Osteoarthritis: Cause and Symptoms
In our last article, we briefly discussed Osteoarthritis and
Rheumatoid Arthritis. This article will take a close look at the
cause, symptoms, and current treatment used for Osteoarthritis.
So let's take a second look at what Osteoarthritis is.
Osteoarthritis is known by many as "wear and tear" Arthritis. It
is one of the most common forms of...
Under normal circumstances, the purines you find in many foods are broken down into uric acid, and the body gets rid of it without any problems. However, for someone with gout, getting rid of this uric acid is problematic, and the result is painful crystals forming in the joints - leading to gout pain. When this happens, there are medications that can help with the pain, but one of the best...
Recently, a gout and diet prevention study was published in by Dr. Hyon K. Choi and Gary Curhan in Arthritis Care & Research's June 2007 issue which examined the fact that, contrary to popular belief, coffee may not be as bad for gout sufferers as previously thought. Although gout patients have been told to stay away from coffee, there may be an ingredient in the beverage that can actually...
canine kidney stones pet | kidney stones be treated | diagnosing kidney stones | gout arthritis treatment | what is uric acid levels | kidney stone home remedy |
CELERY AND FREQUENT URINATION
lemon acid uric
cause of feet heat and pain
causes of high uric acid treatment
low purine foods
salmon causing gout
does coffee effects uric acid?
honey for uric acid
Goutezol
how long to keep ice on gout attack?
|
|
|
| |
| |
|
|
| |
|
|
|
|
